 | The Croods 2 (2020) as Ugga (voice) |
 | Sicario: Day of the Soldado (2018) as Cynthia Foards |
 | Incredibles 2 (2018) as Evelyn Deavor (voice) |
 | Little Pink House (2018) as Susette Kelo |
 | Nostalgia (2018) as Donna Beam |
 | November Criminals (2017) as Fiona |
 | We Don't Belong Here (2017) as Nancy Green |
 | Get Out (2017) as Missy Armitage |
 | Unless (2016) as Reta |
 | Accidental Love (2015) as Rep. Pam Hendrickson |
 | Elephant Song (2014) as Nurse Susan Peterson |
 | Jackass Presents: Bad Grandpa .5 (2014) as Ellie |
 | How and Why (2014) as Alice |
 | War Story (2014) as Lee |
 | Jackass Presents: Bad Grandpa (2013) as Ellie |
 | Captain Phillips (2013) as Andrea Phillips |
 | Enough Said (2013) as Marianne |
 | Begin Again (2013) as Miriam Hart |
 | The Croods (2013) as Ugga Crood (voice) |
 | Maladies (2013) as Catherine |
 | Lost Angels: Skid Row Is My Home (2012) as Narrator |
 | A Late Quartet (2012) as Juliette Gelbart |
 | All Noncombatants Please Clear the Set (2012) |
 | Peace, Love & Misunderstanding (2011) as Diane Hudson |
 | The Oranges (2011) as Paige Walling |
 | Trust (2010) as Lynn Cameron |
 | Cyrus (2010) as Jamie |
 | Percy Jackson & the Olympians: The Lightning Thief (2010) as Sally Jackson |
 | Please Give (2010) as Kate |
 | Where the Wild Things Are (2009) as Connie |
| | Collaborators (2009) as Herself |
 | The Soloist (2009) as Mary Weston |
 | Synecdoche, New York (2008) as Adele Lack |
 | What Just Happened (2008) as Lou Tarnow |
 | Hamlet 2 (2008) as Brie Marschz |
 | Genova (2008) as Barbara |
 | Into the Wild (2007) as Jan Burres |
 | An American Crime (2007) as Gertrude Baniszewski |
 | Friends with Money (2006) as Christine |
 | Capote (2005) as Harper Lee |
 | The 40 Year Old Virgin (2005) as Trish Piedmont |
 | The Interpreter (2005) as Dot Woods |
 | The Ballad of Jack and Rose (2005) as Kathleen |
 | Adaptation. (2002) as Herself (uncredited) |
 | S1m0ne (2002) as Elaine Christian |
 | Full Frontal (2002) as Lee |
 | Death to Smoochy (2002) as Nora Wells |
 | Lovely & Amazing (2001) as Michelle Marks |
 | Being John Malkovich (1999) as Maxine Lund |
 | Simpatico (1999) as Cecilia |
 | 8MM (1999) as Amy Welles |
 | Out of Sight (1998) as Adele |
 | The Real Blonde (1998) as Mary |
 | Your Friends & Neighbors (1998) as Terri |
 | If These Walls Could Talk (1996) as Becky Donnelly |
 | Box of Moonlight (1996) as Floatie Dupre |
 | Walking and Talking (1996) as Amelia |
 | Boys (1996) as Jilly |
 | Heroine of Hell (1996) as Magda |
 | Living in Oblivion (1995) as Nicole Springer |
 | The Gun in Betty Lou's Handbag (1992) as Suzanne |
 | Johnny Suede (1991) as Yvonne |
 | Switch (1991) as Steve's Secretary |
 | Catchfire (1990) as Trucker's girl |
 | Survival Quest (1988) as Cheryl |
 | The Abduction of Allison Tate (1986) as Linda Kellogg |
| | Frank or Francis |
 | God Grew Tired of Us Producer |
